Personalized nutrition for a healthy gut microbiome
These important organisms primarily reside in our gut and are highly diverse in nature with typically over a thousand different species living in our bodies at any given time. These organisms can be bacteria, fungi, protozoa or even viruses. Collectively, all of this genetic material makes up each of our unique microbiomes. Each of these microbes has its own genome, on its own, containing thousands of genes and creating substantially more genetic diversity than our own human genome.
Microbiomes role in our health
Microbes help synthesize certain vitamins and amino acids, for example vitamin B12, thiamine and riboflavin, and Vitamin K, and provide nutrients for our cells.
The microbiota plays a fundamental role on the induction, training and function of our own immune system, regulating human development, influencing our immunity to harmful viruses and bacteria.
An unhealthy gut microbiome can lead to diabetes, obesity, alcoholic liver disease, muscular dystrophy, rheumatoid arthritis, nonalcoholic fatty liver disease, cardiovascular disease, multiple sclerosis & more.
The gut microbiome has also been linked to how individuals respond to certain drugs, including how cancer patients respond to certain chemotherapies.
Nutritional & environmental effects
There is growing recognition of the role of diet and other environmental factors in altering the composition and metabolic activity of the human gut microbiota, which in turn directly impacts health. No two people have exactly the same composition of bacterial species in their guts. Over the years, each of us is exposed to a unique variety of microbes, beginning in our mother’s wombs and continuing throughout our daily lives in the places we live and through the food we eat.
Outside influences such as antibiotic use, diet, and psychological stress have all shown strong correlations with what lives inside our bodies. The good news is, these are all things we have control over and armed with a snapshot of our own microbiome, we can begin to provide our gut with specific needs in order to maintain a healthy microbiome.
Impact on pregnancy & your infant's health
The gut microbiome has an important role in infant health and immune development. As the prenatal period progresses, inflammatory and immune changes alter a mother’s material gut function and bacterial composition. The composition of the maternal gut microbiome affects the outcome of child birth, including preterm birth and neonatal health, and has long-term health implications for both the mother and her child. A mother’s diet is one of the most important factors in regulating the maternal microbiome. The infant’s own gut microbiome is influenced by the maternal diet through vertical transfer of maternal microbes to infants during vaginal delivery and breastfeeding (1).
MaMome’s next-generation metagenomics sequencing
Our understanding of the human microbiome has exponentially grown in the recent years with technological advancements in genome sequencing and metagenomic analysis. The ability to map genetic components of microbes and their functions has given us a better understanding of how they influence our bodies in health and disease. Comprehension of this dynamic ecological community opens the door to the manipulation of the gut microbiome for improved mother and child health.
MaMome aims to prevent health complications during pregnancy by leveraging personalized nutrition that is based on a healthy maternal gut microbiome. We use genomic technologies to characterize the mother’s gut microbial composition and apply our proprietary algorithms to match microbiome data with individual nutritional requirements. Our personalized nutritional recommendations seek to optimize maternal diet and health in order to prevent health complications such as preeclampsia, gestational diabetes, allergies, and asthma. In addition, our microbiome test has the ability to detect pathogens in individuals, including SARS-CoV-2.
MaMome's Machine Learning
We employ modern high-throughput sequencing technologies to characterize the expecting mother’s gut microbial composition. Using our in-house machine learning algorithms, we analyze the microbiome population with the nutrients required to optimize the microbiome health, and consequently both mother’s and baby’s health. By using 16S rRNA genes and shotgun metagenomic sequence reads, we apply a proprietary machine learning pipeline to identify bacterial species, enabling us to detect bacterial pathogens in individuals, as well as find correlations between bacterial species and specific nutrients and diseases (2).
Ahmadian, Elham, et al. "Pre-Eclampsia: Microbiota possibly playing a role." Pharmacological Research 155 (2020): 104692.
Edwards, Sara M., et al. "The maternal gut microbiome during pregnancy." MCN. The American journal of maternal child nursing 42.6 (2017): 310.